Melanoma Molecular Maps Projects


MMMP Databases, putting together the pieces of the Melanoma puzzle. Seven interconnected databanks for the interactive collection, update and consultation of the translational and clinical information on melanoma biology and treatment.
A systematic collection of the scientific knowledge regarding the development of targeted therapy for melanoma. Since data are gathered in a computationally compatible fashion, the database can be utilized for the identification of prevalent therapeutic hypotheses based on the available evidence and for ranking treatments based on the patient's molecular profile (drug ranking system).
Inspired to the principles of functional interactomics, this is a collection of schematic figures depicting the molecular pathways involved in cancer development and progression, with particular regard to melanoma. A close-to-hand visual guide to navigate in the ever-growing complexity of cancer molecular biology.

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Melanoma News

Protease activated receptor-1 (PAR-1) inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype.
Source: Villares GJ, Proc Natl Acad Sci USA 2011, 108:626-31.

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.
Source: Kapoor A, Nature 2010, 468:1105-9.

CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells.
Source: Amatschek S, Br J Cancer 2011, 104:469-79.

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