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Biomap#22

Title: List of PARP inhibitors
 
Legend: Several poly(ADP-ribose) polymerase (PARP) inhibitors are being developed as anticancer agents. PARP are a family of DNA damage sensors (of which PARP-1 is the most abundant and best characterized) involved in single strand DNA breaks via base excision repair (BER). PARP inhibitors (e.g. AG014699, AG14361, AZD2281 / NU1025, BGP-15, CEP-6800, FR255595, INO-1001, NU1085, PD128763, PJ-34) are highly active against malignant cells lacking proteins involved in double strand DNA breaks repair, such as BRCA1 and BRCA2; they also increase synergistically the antitumor activity of DNA damaging agents, such as some chemotherapeutic drugs and ionizing radiations. REFERENCES: [1] Miwa M et al, Cancer Sci 2007, 98:1528-35. [2] Ratnam K et al, Clin Cancer Res 2007, 13:1383-8. [3] Haince JF et al, Trends Mol Med 2005, 11:456-63
Author: The MMMP Team (updated: Oct 2007)

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