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Biomap#25

Title: List of aurora kinase inhibitors
 
Legend: Aurora kinases (AURKA, AURKB, AURKC) are serine/threonine kinases (STK) involved in cell mitosis: AURKA in centrosome maturation and spindle assembly, AURKB is part of the spindle checkpoint regulating chromosome cohesion and bipolar attachment of microtubules, and AURKC is localized at the centrosomes and have a limited expression in testis and in some cancer cell lines. Since they are overexpressed in different tumors, AURKA and (to lower extent) AURKB have been implicated in cancer and tumorigenesis, which led to the development of several inhibitors (e.g. AB-038, AT9283, AURKA shRNA, AZD1152, CYC-116, JNJ-7706621, MLN8054, MP-529, PF-03814735, PHA-680632, PHA-739358, R763, SNS-314, VX-680 [MK0457]). REFERENCES: [1] Fu J et al, Mol Cancer Res 2007, 5:1-10. [2] Naruganahalli KS et al, Curr Opin Investig Drugs 2006, 7:1044-51. Keen N et al, Nat Rev Cancer 2004, 4:927?36
Author: The MMMP Team (updated: May 2008)

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