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Biomap#64

Title: c-MET / HGF pathway
 
Legend: ADCY (adenylate cyclase), AKT (PKB), BAD (BCL2-antagonist of death), b-catenin (beta catenin), Bcl-XL (BCL2-like 1), bFGF (basic fibroblast growth factor), cAMP (cyclic AMP), CBL (ubiquitin ligase E3, UBE3), CD44, CIN85 (SH3KBP1), c-MET (HGF/SF receptor), c-MYC (v-Myc avian myelocytomatosis oncogene homolog), COX2 (cyclooxygenase 2, PTGS2), CREB (cAMP responsive element binding protein), CSK (c-SRC kinase), Cyclin D1 (CCND1), CXCR4 (chemokine C-X-C motif receptor 4), DAG (diacylglycerol), DEP1 (protein tyrosine phosphatase PTPRJ), E-cadherin (CDH1), EGF (epidermal growth factor), EGFR (EGF receptor), EGR1 (early growth response 1), ELK1 (ETS oncogene family), ERK1 (mitogen activated protein kinase 3, MAPK3), ETS1 (v-Ets avian erythroblastosis E26 oncogene homolog 1), FAK (focal adhesion kinase), Fibronectin (FN1), Gab1 (GRB2-associated binding protein 1), Grb2 (growth factor receptor-bound protein 2), HGF (hepatocyte growth factor; scatter factor, SF), HIF (hypoxia inducible factor), Hyaluronic acid; IkB (inhibitor of NFkB), IKK (IkB kinase), IL-1, IL-8 (interleukin-1, -8), Integrin, IP3 (inositol trisphosphate), JNK1 (MAPK8; stress activated protein kinase 1, SAPK1), LEF1 (lymphoid enhancer-binding factor 1, TCF1alpha), MC1R (melanocortin 1 receptor), MEK1 (MAP2K1), MEK4 (MAP2K4), MEKK4 (MAP3K4), MITF (microphthalmia associated transcription factor), MMP (matrix metalloproteinase), MSH (melanocyte stimulating hormone), MSP (macrophage stimulating 1, MST1), mTOR (mammalian target of rapamycin), NFkB (nuclear factor kappa B), ODC (ornithine decarboxylase), Osteopontin (OPN; secreted phosphoprotein 1, SPP1), PAK1 (p21/Cdc42/Rac1-activated kinase 1), PAX3 (paired box 3), PDK1 (PIP3 dependent kinase), PI3K (phosphatidyl-inositol 3 kinase), PIP2, PIP3 (phosphatidyl-inositol bis- tris-phosphate), PKA (protein kinase A), PKC (protein kinase C), PLCg (phospholipase C gamma), Plexin B (PLXB), Proteasome, PTEN (phosphatase and tensin homolog), PTPa (protein tyrosine phosphatase alpha, PTPRA), PTP1B (protein tyrosine phosphatase, PTPN1), PTP2C (protein tyrosine phosphatase 2 C, Shp2), RAC1 (Ras-related C3 botulinum toxin substrate 1), RAF (v-Raf murine sarcoma oncogene homolog), RAS (v-Ras rat sarcoma oncogene homolog), RON (MSP/MST1 receptor, MST1R), Semaphorin (SEMA), SHC (Src homology 2 domain containing), SOS1 (son of sevenless homolog 1), Snail (Snail homolog, SLUG), SRC (v-Src avian sarcoma oncogene homolog, c-SRC), STAT3 (signal transducer and activator of transcription 3), Survivin (baculoviral IAP repeat-containing 5, BIRC5), TNF (tumor necrosis factor), TWIST (Twist homolog), uPA (urokinase plasminogen activator), uPAR (uPA receptor), VEGF (vascular endothelial growth factor), XIAP (X-linked inhibitor of apoptosis). REFERENCES: [1] Boccaccio C et al, Nat Rev Cancer 2006, 6:637-45. [2] Migliore C et al, Eur J Cancer 2008, 44:641-51. [3] Lesko E et al, Front Biosci 2008, 13:1271-80. Figure #64
Author: The MMMP Team (updated: May 2008)

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