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Biomap#67

Title: Cyclooxygenase (COX) and prostanoids pathways
 
Legend: ABCC1 ABCC4 (ATP binding cassette C1, C4), ADCY (adenylate cyclase), AKT (protein kinase B, PKB), ALOX5 (arachidonate 5-lipoxygenase), Annexin (lipocortin), Arachidonic acid, Axin, b-arrestin (beta-arrestin), b-catenin (beta-catenin), BLT (LTB4 receptor), BRAF (v-Raf murine sarcoma viral oncogene homolog B), Calcineurin, Calmodulin, c-Myc, COX1 (cyclooxygenase 1), COX2 (cyclooxygenase 2), CREB (cAMP response element binding protein), Cyclin D1, CYP2J2 (cytochrome P450 epoxygenase), CysLT (cysteinyl leukotriene receptor), DAG (diacylglycerol), DP (PGD2 receptor), EETs (epoxyeicosatrienoic acids), ELK1 (ETS oncogene family member), EP1 EP2 EP3 EP4 (PGE2 receptors), EPAC (Exchange factor directly activated by cAMP, RAP-GEF), ERK (Extracellular signal-regulated kinase, MAPK), FAK (focal adhesion kinase), FP (PGF2 receptor), GEF (guanine nucleotide exchange factor), G-proteins (Galpha [GaS, GaI, GaQ], Gbeta, Ggamma), GRB2 (growth factor receptor bound protein 2), GRK (G-protein coupled receptor [GPCR] kinase), GSK3b (glycogen synthase kinase 3 beta), HPETE (hydroperoxyeicosatetraenoic acid), IkB (inhibitor of NFkB), IKK (IkB kinase), IP (PGI2 receptor), IP3 (inositol trisphosphate), JNK (c-Jun kinase, stress activated protein kinase [SAPK], mitogen activated protein kinase 8 [MAPK8]), LTA4 LTB4 LTC4 LTD4 LTE4 (leukotrienes), MEK (MAPK ERK kinase), NFAT (nuclear factor of activated T-cells), NFkB (nuclear factor kappa B), NR3C1 (nuclear receptor 3C1, glucocorticoid receptor), Paxillin, PDK1 (PIP3 dependent kinase 1), PGDH (prostaglandin dehydrogenase), PGD2 (prostaglandin D2), PGDS (PGD2 synthase), PGF2 (prostaglandin F2), PGFS (PGF2 synthase), PGI2 (prostaglandin I2, prostacyclin), PGIS (PGI2 synthase), PGE2 (prostagliandin E2), PGES (PGE2 synthase), PI3K (phosphatidyl inositol 3 kinase), PIP2 PIP3 (phosphatidyl inositol bis-/tris-phosphate), PKA (protein kinase A), PKC (protein kinase C), PLA2 (phospholipase A2), PLCb (phospholipase C beta), PPAR (peroxisome proliferator activated receptor), PTEN (phosphatase and tensin homolog), RAC (Ras related Rho family member), RAP1 (Ras related protein 1), RAS, SHC (Src homology 2 domain containing), SOS (son of sevenless homolog), SRC (c-Src), TP (TXA2 receptor), TXA2 (thromboxane A2), TXAS (TXA2 synthase). REFERENCES: [1] Wang MT et al, Cancer Metastasis Rev 2007, 26:525-34. [2] Perwez Hussain S et al, Int J Cancer 2007, 121:2373-80. Figure #67
Author: The MMMP Team (updated: June 2008)

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