Melanoma Molecular Maps Projects



Title: Hedgehog pathway
Legend: The hedgehog (HH) signaling pathway regulates the development of many organs in mammals as well as normal stem cells (e.g. hair-follicle stem cells). Aberrant regulation of signalling mechanisms that normally orchestrate embryonic development, such as the Hedgehog, Wnt and Notch pathways is widely observed in human cancers, including melanoma. REFERENCES: [1] Rubin LL et al, Nat Rev Drug Discov 2006, 5:1026-33. [2] Tung DC et al, Future Oncol 2007, 3:569-74. [3] Xie J, Curr Oncol Rep 2008, 10:107-13. [4] Ruiz i Altaba A et al, Trends Cell Biol 2007, 17:438-47. [5] Stecca B et al, Proc Natl Acad Sci USA 2007, 104:5895-900. CITED MOLECULES: AKT (protein kinase B, PKB), b-catenin (beta-catenin, CTNNB), bTrCP (beta-transducin repeat containing), CDO (Cell adhesion molecule-related/down-regulated by oncogenes, CDON homolog), CK1a (casein kinase 1 alpha), c-Myc (v-Myc avian myelocytomatosis viral oncogene homolog), Cyclin D1 (CCND1), DHH (desert hedgehog), Dispatched (DISP, dispatched homolog), E-cadherin (CDH1), FOXM1 (forkhead box M1), GAS1 (growth arrest specific 1), GLI1 (glioma-associated oncogene homolog 1), GLI2 (GLI-Kruppel family member GLI2), GLI3 (GLI-Kruppel family member GLI3), GLI3-R (GLI3 repressor), GPC3 (glypican-3, Dally homolog), GSK3b (glycogen synthase kinase 3 beta), HDM2 (human homolog of mouse double minute-2, MDM2), HES1 (hairy and enhancer of split 1), HIP (hedgehog interacting protein), IHH (indian hedgehog), MEK (mitogen activated protein kinase kinase, MAP2K), MITF (microphthalmia transcription factor), NOTCH, PDGFRa (platelet derived growth factor receptor alpha), PDK1 (PIP3 dependent kinase 1), PI3K (phosphatidyl inositol 3 kinase), PKA (protein kinase A), PP2A (protein phosphatase 2A), PTCH (patched homolog), PTEN (phosphatase and tensin homolog), Rab23 (RAS oncogene family member), RAF (v-Raf murine sarcoma viral oncogene homolog), RAS (v-Ras rat sarcoma viral oncogene homolog), SHH (sonic hedgehog), SMAD3 (Mothers against decapentaplegic homolog 3), SMO (smoothened homolog), SNAIL (Snail homolog, SLUG homolog), SuFu (suppressor of fused homolog), TCF4 (transcription factor 4), Tectonic (TCTN), TGFb (transforming growth factor beta), TGFBR (TGFb receptor), WNT. Figure #70
Author: The MMMP Team (updated: June 2008)

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