Melanoma Molecular Maps Projects



Title: EGFR family
Legend: REFERENCES: [1] Ciardiello F, N Engl J Med 2008, 358:1160-74. [2] Sergina NV, Trends Mol Med 2007, 13:527-34. [3] Lo HW, Br J Cancer 2007, 96 Suppl:R16-20. [4] Oda K, Mol Syst Biol 2005, 1:2005.0010. CITED MOLECULES: 4EBP (eukaryotic translation initiation factor 4E binding protein 1), ADAM (ADAM metallopeptidase), Akt (PKB), Amphiregulin, ARP2/3 complex, b-actin, BAD (BCL2-antagonist of cell death), b-catenin, Betacellulin, BIM (BCL2L11, BCL2-like 11), CAMK2 (calcium/calmodulin-dependent protein kinase, CaM kinase, II), CBL (Cas-Br-M murine ecotropic retroviral transforming sequence), Cdc42 (RHG01, Rho GTPase-activating protein 1), c-Fos (v-fos murine osteosarcoma viral oncogene homolog), CHN1 (chimerin 1), c-Jun (v-jun oncogene homolog), c-Myc (v-myc myelocytomatosis viral oncogene homolog), Cofilin, Cool-1 (Rho guanine nucleotide exchange factor (GEF) 7), CRAF (v-raf-1 murine leukemia viral oncogene homolog 1), CREB (cAMP responsive element binding protein 1), DAG (diacylglycerol), EGF (epidermal growth factor), EGFR (EGF receptor, HER1, ErbB1), eIF4E (eukaryotic translation initiation factor 4E), ELK (ELK1, member of ETS oncogene family), Epiregulin, ErBb2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2), ERK (MAPK1, mitogen activated protein kinase 1), FasL (Fas ligand), FOXO3a (forkhead box O3), Gab1 (GRB2-associated binding protein 1), GPCR (G protein coupled receptor), Grb2 (GRB2-associated binding protein 2), GSK3 (glycogen synthase kinase 3), HBEGF (heparin-binding EGF-like growth factor), HDM2 (Mdm2 p53 binding protein homolog), HER (human EGF receptor family), HER3 (HerbB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3), HER4 (HerbB4), IKK (IkB kinase), IP3 (inositol 1,4,5-trisphosphate), JNKK (MAP2K4), LIMK (LIM domain kinase 1), MEK (MAP2K1), mTOR (mammalian target of rapamycin), NFkB (nuclear factor kappa B), NRG1 (neuregulin 1), NRG2, NRG3, NRG4, NWASP (Neural Wiskott-Aldrich syndrome protein), p21, p27, PAK (p21/Cdc42/Rac1-activated kinase), PDK1 (PIP3 dependent kinase 1), Phosphatidyl acid, PI3K (phosphatidyl inositol 3 kinase), PI4P (phosphatidyl inositol 4 phosphate), PI5K (PI4P kinase), PIP2 (PI bis-phosphate), PIP3 (PI tris-phosphate), PKC (protein kinase C), PLCbeta (phospholipase C beta), PLD (phospholipase D), PP2A (protein phosphatase 2A), PP2B (protein phosphatase 2B), Proteasome, PTEN (phosphatase and tensin homolog), Pyk2 (PTK2B protein tyrosine kinase 2), Rab5a (RAB5A, member RAS oncogene family), RAC (ras-related C3 botulinum toxin substrate 1, rho family, small GTP binding protein Rac1), RAF (v-Raf murine sarcoma viral oncogene homolog), RAS (v-Ras viral oncogene homolog), Ras-GAP (Ras GTPase activating protein), Rho (H12 ras homolog gene family), RhoA (Rho family, member A), Rock1 (rho-associated, coiled-coil containing protein kinase 1), RS6K (ribosomal protein S6 kinase), SCF complex (Skp Cullin F-box), SGK (serum/glucocorticoid regulated kinase 1), SHC (Src homology 2 domain containing), SOS (son of sevenless homolog), SRC (v-Src avian sarcoma oncogene homolog,) SSH (slingshot phosphatase homolog, Drosophila), STAT1 (signal transducer and activator of transcription 1), STAT3, TGFa (transforming growth factor alpha), TRAIL (TNF related apoptosis inducing ligand), TSC (tuberous sclerosis complex). Figure #75
Author: The MMMP Team (updated: September 2008)

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