Melanoma Molecular Maps Projects



Title: JNK (c-Jun N-terminal kinase) biology
Legend: REFERENCES: [1] Alexaki VI, Pigment Cell Melanoma Res 2008, 21:429-38. [2] Weston CR, Curr Opin Cell Biol 2007, 19:142-9. [3] Bode AM, Mol Carcinog 2007, 46:591-8. [4] Heasley LE, Mol Cells 2006, 21:167-73. CITED MOLECULES: ASK1 (MAP3K5, mitogen-activated protein kinase kinase kinase 5), ATF2 (activating transcription factor 2), BAD (BCL2-associated agonist of cell death), BAK (BCL2-antagonist/killer 1), BAX (BCL2-associated X protein), Bcl-2 (B-cell CLL/lymphoma 2), Betulinic acid, BIM (BCL2L11, BCL2-like 11 apoptosis facilitator), Calcineurin, Cdc42 (RHG01, Rho GTPase-activating protein 1), CDK4 (cyclin-dependent kinase 4), c-Jun (v-jun oncogene homolog), CRK (v-crk sarcoma virus CT10 oncogene homolog), Cyclin D1, Docetaxel, FAK (focal adhesion kinase), FASL (Fas ligand), Gadd45b (growth arrest and DNA-damage-inducible, beta), GEF (guanine exchange factor), GPCR (G protein coupled receptor), HPK (MAP4K1), IL-1 (IL1, interleukin 1), JNK1 (MAPK8, c-JUN N-terminal kinase), JNK2 (MAPK9), JNK3 (MAPK10), Mek4 (MAP2K4), Mek7(MAP2K7), MEKK4 (MAP3K4), NFAT (nuclear factor of activated T-cells), NFkB (nuclear factor kappa B), Noxa (NADPH oxidase activator 1) , p21 (Cip1/Waf1), p38 (MAPK14), p53, Paclitaxel, PAK (p21/Cdc42/ Rac-activated kinase ), Paxillin, PI3K (phosphatidyl inositol 3 kinase), PKC (protein kinase C), Plitidepsin, PYK2 (PTK2B protein tyrosine kinase 2 beta), RAC/RAC1 (ras-related C3 botulinum toxin substrate, rho family, small GTP binding protein Rac), Rack1 (G protein, beta polypeptide 2-like 1), RAS (v-Ras viral oncogene homolog), ROS (reactive oxygen species) , RTK (receptor tyrosine kinase), SGK (serum/glucocorticoid regulated kinase), SP600125, TAK1 (MAP3K7), TNF (tumor necrosis factor), TRX (thioredoxin), Vincristine. Figure #76
Author: The MMMP Team (updated: September 2008)

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