Melanoma Molecular Maps Projects



Title: FoxO pathways
Legend: Forkhead transcription factors have a "winged helix" domain and regulate processes that range from cell longevity to cell death. The mammalian forkhead family members in the O class (FoxO) play a significant role in different disorders including cancer (including melanoma [4]), diabetes, infertility, neurodegeneration and immune system dysfunction. REFERENCES: [1] Maiese K, Trends Mol Med 2008, 14:219-27. [2] Fu Z, Oncogene 2008, 27:2312-9. [3] Calnan DR, Oncogene 2008, 27:2276-88. [4] Hilmi C, Pigment Cell Melanoma Res 2008, 21:139-46. CITED MOLECULES: 14-3-3 (adaptor protein), AEG1 (Astrocyte elevated gene-1, MTDH, Lyric), AKT (protein kinase B, PKB), AR (androgen receptor), Rbx1 (ring box 1, ROC1), Bcl-xL (Bcl-2 like 1, BCL2L1), beta-catenin, Bim (BCL2-like 11 apoptosis facilitator, BCL2L11), Catalase, CBP (CREBBP, CREB binding protein), CD62-L (selectin-L), CDK1 (cyclin dependent kinase 1), Cisplatin, Cited2 (Cbp/p300-interacting transactivator 2, MRG-1), c-Myc (v-Myc oncogene homolog), CRM1 (XPO1, Exportin-1), CUL1 (Cullin-1), Cyclin B, Cyclin D1, Cyclin D2, DBC1 (deleted in bladder cancer 1, FAM5A), EDG1 (sphingosine-1-phosphate receptor 1), EGF (epidermal growth factor), ER (estrogen receptor), FasL (Fas ligand), FBXP (F-box protein), FoxA1 (HNF3A), FoxA2 (HNF3B), FoxA3 (HNF3G), FoxB1 (FKH5), FoxB2, FoxC1 (FKHL7), FoxC2 (FKHL14), FoxD1 (FKHL8), FoxD2 (FKHL17), FoxD3 (HFH2), FoxD4 (FKHL9), FoxD5 (FOXD4L1), FoxE1 (FKHL15), FoxE3 (FKHL12), FoxF1 (FKHL5), FoxF2 (FKHL6), FoxG1 (FKHL1-4), FoxH1 (FAST1), FoxI1 (FKHL10), FoxI2 , FoxJ1 (FKHL13), FoxJ2 (GHX), FoxJ3, FoxK1, FoxK2 (ILF1), FoxL1 (FKHL11), FoxL2 (BPES), FoxM1 (FKHL16), FoxN1 (FKHL20), FoxN2 (HTLF), FoxN3 (CHES1), FoxN4, FoxO (forkhead box O1), FoxO1 (FKHR, FKH1, FoxO1a) FoxO3 (FKHRL1, FoxO2, FoxO3a), FoxO4 (AFX1, MLLT7), FoxO6, FoxP1 (QRF1), FoxP2 (SPCH1), FoxP3 (IPEX), FoxP4, FoxQ1 (HFH1), FoxR1 (FOXN5), FoxR2 (FOXN6), FoxS1 (FKHL18), Gadd45 (growth arrest and DNA damage inducible alpha), H2O2 (hydrogen peroxide), HIF1 (hypoxia inducible factor 1), KLF2, IGF1 (insulin like growth factor 1), IGF1R (IGF1 receptor), IKK beta (IkB [inhibitor of NFkB] kinase subunit beta), INK4B (CDKN2B, Cyclin-dependent kinase 4 inhibitor B), JNK (c-Jun N-terminal kinase, MAPK), Leptomycin B, LY294002, MAX (Myc-associated factor X), Mcl-1 (myeloid cell leukemia sequence 1), MDM2 (HDM2, human double minute 2 [E3 ubiquitin ligase]), MDR1 (multidrug resistance protein 1, ABCB1), Mxi1 (MAX interacting protein 1), Nicotinamide, NIX (BCL2/adenovirus E1B interacting protein 3 like, BNIP3L), p15 (CDKN2B, CDK inhibitor 2 B), p19/ARF (murine homolog of human p14/ARF), p19 (CDKN2D, CDK inhibitor 2 D), p21 (CIP1, WAF1, CDKN1A), p27 (KIP1, CDKN1B), p53, p120, Paclitaxel, PBX1 (pre B cell leukemia homeobox transcription factor 1), PDK1 (PIP3 dependent kinase 1), PDK2, PI3K (phosphatidyl-inositol 3 kinase), Pin1 (peptidyl isomerase NIMA-interacting 1), PIP2/PIP3 (phosphatidyl-inositol bis-/tris-phosphate), Plakoglobin, PLK (polo like kinase), PP2A (protein phosphatase 2A), Procyanidin, Pronasterone A, Proteasome, Psammaplysene A, PTEN (phosphatase and tensin homolog), RAG1/2 (recombination activating gene 1 and 2), Resveratrol, RTP801 (DNA damage inducible transcript 4, DDIT4), Runx3 (runt-related transcription factor 3), SCF complex (Skp Cullin F-box complex), SDF1 (stromal cell-derived factor 1, CXCL12), SGK (serum/glucocorticoid regulated kinase), siRNA (small interfering RNA), Sirt1 (NAD-dependent deacetylase sirtuin 1, hSIRT1), SKP (S-phase kinase-associated protein), SMAD (mothers against decapentaplegic homolog), SOD (superoxide dismutase), Sprouty 2, Survivin (baculoviral IAP repeat-containing 5, BIRC5), TCF (T cell factor, LEF1), TRAIL (TNF related apoptosis inducing ligand), Tweak (TNF-like weak inducer of apoptosis), Ubc (ubiquitin-conjugating enzyme), VE-cadherin. Figure #80
Author: Andrea Taddei (Milan - Italy;; Georges Bismuth (Paris - France; Updated: December 2008

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