Melanoma Molecular Maps Projects

Padova

MMMP Databases, putting together the pieces of the Melanoma puzzle. Seven interconnected databanks for the interactive collection, update and consultation of the translational and clinical information on melanoma biology and treatment.
A computational tool for the automated analysis of the data collected in the Targeted Therapy Database (TTD). The TTA enables users to easily implement the algorithms necessary to summarize the literature data and to match the tumor/patient molecular profile with the available evidence on the molecularly targeted therapy of melanoma.
A systematic collection of the scientific knowledge regarding the development of targeted therapy for melanoma. Since data are gathered in a computationally compatible fashion, the database can be utilized for the identification of prevalent therapeutic hypotheses based on the available evidence and for ranking treatments based on the patient's molecular profile (drug ranking system).
Inspired to the principles of functional interactomics, this is a collection of schematic figures depicting the molecular pathways involved in cancer development and progression, with particular regard to melanoma. A close-to-hand visual guide to navigate in the ever-growing complexity of cancer molecular biology.
Therapy-oriented information on the molecules that make up melanoma (and cancer in general). Organized in structured formats, the data are linked to the information contained in the other MMMP databases to cover the details of translational and clinical interest.
Aimed at providing a molecular identikit of human melanoma, this is intended as a comprehensive list of the molecules (and their main features) expressed and/or altered in this type of cancer.
A databank dedicated to the description at the molecular level of traditional and innovative anti-melanoma agents, with particular regard to the development of tumor-targeted patient-tailored therapeutic strategies.
A systematic collection of the most significant results of clinical trials for the management of patients with malignant melanoma. Ranging from randomized controlled clinical studies and meta-analyses of traditional therapies to feasibility trials of the most innovative therapeutic approaches.
Biomolecules and drugs cited in the MMMP website are automatically listed in this databank. In addition, cancer-related terms, definitions and concepts are briefly described. All items are linked to the information available in the relative MMMP Databases.

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Melanoma News

PAR-1 AND MASPIN
Protease activated receptor-1 (PAR-1) inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype.
Source: Villares GJ, Proc Natl Acad Sci USA 2011, 108:626-31.

MACRO-H2A
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.
Source: Kapoor A, Nature 2010, 468:1105-9.

CXCL9
CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells.
Source: Amatschek S, Br J Cancer 2011, 104:469-79.

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